The three star San Antonio de La Florida Hotel is located in Madrid city, opposite the Príncipe Pío railway and underground station and close to Plaza de España, Gran Vía and the Royal Palace. From the hotel guests have access to the M-30 and M-40 motorways to Madrid-Barajas airport, Chamartín railway station and the Campo de las Naciones fair/show area.

The hotel is in a building that dates back to 1964, and can accommodate 199 guests. The hotel has 99 rooms, of which 80 are doubles and 19 are singles. Every room has an outside window and bathroom. 68 rooms have air conditioning and six have a balcony. Every room has satellite colour television and telephone. There are also 33 extra folding beds and cots available.

Facilities at the San Antonio de La Florida include a lift, area with rooms for smokers, indoor private parking, function room with capacity for 50 people, a restaurant (open to guests and the public) , café and bar.

.